JMJD3/HDAC-IN-1
JMJD3/HDAC-IN-1 thumbnail 1
GTR07521269

JMJD3/HDAC-IN-1

agar-broth-antibody

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Description

JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HDAC1, IC50=16 nM) . JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].

Specifications

CAS Number
2883046-06-6
Shipping
Room temperature

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